Description
General description
Rethink your bioinks with TissueFab®
About the material:
The TissueFab(R) PODS Growth Factor Loaded Bioink Kit, cell proliferation, facile curable contains:
Low endotoxin gelatin based bioink
Human FGF-2 PODS
Human VEGF-165 PODS
Human TGF-β1 PODS
Printing and crosslinking parameters:
Suitable for extrusion-based bioprinting
Crosslinked using TissueFab bioink crosslinking solution (Cat # 919926)
TissueFab PODS Growth Factor Loaded Bioink kit, Cell Proliferation, facile curable is a ready-to-use bioink kit which is formulated for high cell viability, printing fidelity, and is designed for extrusion-based 3D bioprinting. The bioink component has been formulated to crosslink without the necessity of light irradiation which can be detrimental to cell health. It contains a Gelatin base which as a natural protein offers excellent cytocompatibility and cell-binding motifs in order to mimic the native extracellular (ECM) microenvironment. The bioink can be crosslinked in a dilute solution of multivalent cations including TissueFab - crosslinking solution (Cat#919926). TissueFab - Facile curable HA bioink also contains hyaluronic acid (HA), a natural polysaccharide found ubiquitously thorughout the body and cellular ECM. Cell can recognize HA through cell surface receptors CD44 and RHAMM and also degrade it through secreation of hyaluronidase.[1]. TissueFab PODS Growth Factor Loaded Bioink kit, Cell Proliferation, facile curable can be used with most extrusion-based bioprinters, is biodegradable, and is compatible with human mesenchymal stem cells (hMSCs).
Included growth facors, FGF-2, VEGF-165, and TGF-β1 are known to play crucial roles in regulating cell growth, proliferation, angiogenesis, or cell survival. Their inclusion with PODS delivery system allows their sustained release within bioprinted constructs and retainment of 70% bioactivity after 6 months. When mixed with the bioink component, the included PODS® growth factors can promote cell growth and proliferation.
More information and a step by step protocol can be found under the "More Documents" section of this page.
Application
TissueFab® PODS Growth Factor Loaded Bioink kit, Cell Proliferation, facile curable enables the precise fabrication of 3D cell models and tissue constructs for research in 3D cell biology, tissue engineering, in vitro tissue models, and regenerative medicine.
Features and Benefits
Key Features and Benefits:
Each TissueFab® bioink is developed and tested to meet strict criteria to best suit researchers′ needs.This includes:
Printability and rheological properties
Crosslinking
Cell viability
Biocompatibility
Low bioburden
Low endotoxin
This product contains 10 ml of bioink solution and growth factors PODS® packaged separately to allow for optimization.
Legal Information
PODS is a registered trademark of Cell Guidance Systems Ltd
TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany
