Merck, A5762-1G, Adenine 9-β-D-arabinofuranoside

Name: Adenine 9-β-D-arabinofuranoside
Brand: Merck
SKU: A5762-1G

Size:1 g, 9-β-D-Arabinofuranosyladenine, Ara-A, Vidarabine, ≥99%

Catalog Number: A5762-1G

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Category

Mixed-Mode Resins

Pack Size1 g

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Adenine 9-β-D-arabinofuranoside (AraA) is a nucleoside analog. It is an antiviral drug and targets viral DNA polymerases and is majorly used for treating herpes simplex viral infection. It is a potent inhibitor of AMP-activated protein kinase (AMPK). It also inhibits cardiac type 5 adenylyl cyclase but does not improve pathology in cardiovascular diseases.
Application
Used to study the roles of AMP-activated protein kinase (AMPK) in cell signaling.
Adenine 9-β-D-arabinofuranoside has been used for the inhibition of 5′ AMP-activated protein kinase (AMPK) in liver, muscle and cardiac cells H9c2.
Biochem/physiol Actions
Cell-permeable adenylate cyclase inhibitor; in detergent-dispersed rat brain preparation, IC₅₀ = 30 μM. Clinically significant antiviral agent, especially against herpes simplex (HSV), by inhibition of DNA polymerase.
Cell-permeable adenylyl cyclase inhibitor. IC₅₀ = 30 μM in detergent-dispersed rat brain preparation.

Specifications

General

UNSPSC Code	12352202
NACRES	NA.77
PubChem Substance ID	24891019
EC Number	226-893-9
Beilstein/REAXYS Number	624881
MDL number	MFCD00065471
InChI key	OIRDTQYFTABQOQ-UHTZMRCNSA-N
InChI	1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7+,10-/m1/s1
SMILES string	Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O
assay	≥99%
form	powder
antibiotic activity spectrum	viruses
mode of action	DNA synthesis \| interferes
storage temp.	−20°C
Quality Level	100
Gene Information	mouse ... Ahcy(269378)

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