Merck, A9810-.1MG, Amyloid β Protein Fragment 1-42

General description
Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.
Application
Amyloid β Protein Fragment 1-42 has been used:
for the preparation of Aβ 1-42 oligomer
for western blot analysis
for the interference test of immunomagnetic reduction (IMR) plasma Aβ42 assay
to study the effects of resveratrol on Aβ 1-42-induced impairment of spatial learning, memory and synaptic plasticity
to investigate the effect of Aβ in epithelial cell culture

Biochem/physiol Actions
The predominant fragment of amyloid β-protein found in the brains of patients with Alzheimer′s disease and Down′s syndrome.
Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties.