Merck, C5732-5MG, CA-074

Name: CA-074
Brand: Merck
SKU: C5732-5MG

Size:5 mg, (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline, ≥98% (HPLC)

Catalog Number: C5732-5MG

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Category

Phosphatase Inhibitors

Pack Size5 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
CA-074 has been used as a cathepsin B inhibitor:
to study its effect on pseudotyped viruses bearing S proteins harboring R642M and N714K using HeLa cells
to determine the role of autophagy in glucose deprivation (GD)-induced damage
to study its effects on neuronal function upon exposure to His-cathepsin B (CATB)

Biochem/physiol Actions
CA-074 is a potent and a selective inhibitor of cathepsin B. It is useful to study the biological function of cathepsin B in vivo. Studies show that CA-074 can also inhibit cathepsin L under reducing conditions.

Specifications

General

UNSPSC Code	12352200
PubChem Substance ID	24892580
NACRES	NA.77
Web Name Suffix Override	synthetic (organic), ≥98% (HPLC), cathepsin B inhibitor, powder
MDL number	MFCD00797531
SMILES string	CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H]([C@H](C)CC)C(=O)N2CCC[C@H]2C(O)=O
InChI key	ZEZGJKSEBRELAS-NSIINPIOSA-N
InChI	1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)/t10?,11-,12-,13-,14-/m0/s1
biological source	synthetic (organic)
assay	≥98% (HPLC)
form	powder
solubility	methanol: 1 mg/mL, clear, colorless
storage temp.	−20°C
Quality Level	200

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