Merck, L4129, <SC>L</SC>-α-Lysophosphatidylcholine from egg yolk

Application
L-α-Lysophosphatidylcholine from egg yolk has been used:
as a surfactant
as a media supplement and in Staphylococcus aureus inhibition assay in dermatitis
as a demyelinating agent for nerve
as a component in sperm nuclei preparation buffer

Biochem/physiol Actions
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun.
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na⁺ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K⁺ channels.
Preparation Note
Prepared by the action of phospholipase A on egg L-α-phosphatidylcholine.
Analysis Note
Contains primarily palmitic and stearic acids.