Merck, MAB348, Anti-APP A4 Antibody, a.a. 66-81 of APP {NT}, clone 22C11

Name: Anti-APP A4 Antibody, a.a. 66-81 of APP {NT}, clone 22C11
Brand: Merck
SKU: MAB348

Size:50 μg, APP, Anti - APP A4, Anti-amyloid precursor protein A4, clone 22C11, Chemicon®, from mouse

Catalog Number: MAB348

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Category

Recombinant Antibodies

Pack Size50 µg

TagsPrimary antibodies Antibodies Protein Biology

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
The β/A4 amyloid precursor protein (APP) is a transmembrane glycoprotein and exists in three isoforms. This protein is composed of a single-pass transmembrane domain, a large extracellular N-terminal domain, and a short cytoplasmic C-terminal tail. The APP gene is located on the human chromosome at 21q21.3-q22.
110/120/130 kDa
Immunogen
Epitope: a.a. 66-81 of APP {N-terminus}
Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein.
Application
Anti-APP A4 Antibody, a.a. 66-81 of APP , clone 22C11 has been used in immunohistochemistry and immunoblotting(1:1000).
Biochem/physiol Actions
Anti-APP A4 Antibody reacts with pre-A4 and recognizes amino acids 66-81 of the N-terminus on the pre-A4 molecule (Hilbich et al., 1993). 22C11 recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa (Hoffmann et al., 2000). The Anti-APP A4 antibody is known to cross-react with APLP2 (Slunt, 1994).
The β/A4 amyloid precursor protein (APP) undergoes proteolytic cleavage and produces β/A4 peptide. The extracellular deposition of this peptide is observed in brain cortical parenchyma and cerebro-meningeal blood vessels which marks the pathological condition of Alzheimer′s disease. Mutations of the APP gene lead to the early onset of Alzheimer′s disease and hereditary cerebral hemorrhage with amyloidosis.
Physical form
Format: Purified
Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Protein A purified
Preparation Note
Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Analysis Note
Control
Brain tissue, brain cell lysates
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Specifications

General

UNSPSC Code	12352203
eCl@ss	32160702
Web Name Suffix Override	CHEMICON®, mouse monoclonal, 22C11
Web Name Override	Anti-Beta (β)-Amyloid antibody
NACRES	NA.41
biological source	mouse
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	22C11, monoclonal
species reactivity	rat, fish, human, mouse, canine, pig, monkey
manufacturer/tradename	Chemicon®
technique(s)	immunofluorescence: suitable
isotype	IgG1
NCBI accession no.	NM_000484.2
UniProt accession no.	P05067
shipped in	dry ice
target post-translational modification	unmodified
Quality Level	100
Gene Information	human ... APP(351)

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Merck, MAB348, Anti-APP A4 Antibody, a.a. 66-81 of APP {NT}, clone 22C11

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