Merck, MABS817, Anti-AGT, clone 1B1 Antibody

General description
Angiotensinogen (AGT) is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Immunogen
Purified recombinant fragment of human AGT expressed in E. Coli.
Application
Detect AGT using this Anti-AGT, clone 1B1 Antibody validated for use in Western Blotting.
Analysis Note
Evaluated by Western Blotting in human plasma.

Western Blotting Analysis (WB): A 1:500-2,000 dilution of this antibody detected AGT in human plasma.
Other Notes
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial