Merck, SBR00089-5MG, Sotorasib

Name: Sotorasib
Brand: Merck
SKU: SBR00089-5MG

Size:5 mg, AMG-510, ≥98% (HPLC), solid

Catalog Number: SBR00089-5MG

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Category

Mixed-Mode Resins

Pack Size5 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Sotorasib (INN) is a small molecule which belongs to the class of compounds known as KRAS G12C inhibitors. Sotorasib is a chiral compound which is a KRAS G12C covalent inhibitor.
Biochem/physiol Actions
Sotorasib inhibits the KRAS G12C protein, which is involved in the regulation of cell growth and division. The KRAS G12C protein is a mutated form of the KRAS protein, which is found in certain types of cancer cells, particularly non-small cell lung cancer (NSCLC). The G12C mutation causes abnormal activation of the KRAS G12C protein, leading to the uncontrolled growth and spread of cancer cells.

Specifications

General

UNSPSC Code	51101500
NACRES	NA.41
InChI	InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1
InChI key	NXQKSXLFSAEQCZ-SFHVURJKSA-N
SMILES string	C[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C
assay	≥98% (HPLC)
form	solid
color	off-white to yellow
mode of action	protein synthesis \| inhibits
Quality Level	100

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