General descriptionSquamous cell carcinoma (SCC) is a common cancer type, developing in epithelial cells. Nearly all cancers of the oral cavity are squamous cell carcinomas, and the high recurrence rate among oral SCCs make these challenging targets for therapies. Established models of this cancer type continue to yield significant insights into the properties and potential treatments of head and neck cancers
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The OECM-1 human oral cavity squamous cell carcinoma cell line is a well-established model for squamous cell carcinoma. The OECM-1 cell line harbors a missense mutation in the p53 tumor suppressor , displays low EGFR expression , and is tumorigenic in nude mice . OECM-1 cells proliferate with a doubling time of 30-38 hours and are capable of anchorage-independent growth, forming spheroid colonies . OECM-1 cells have been intensively characterized in the literature for morphology, biomarker expression and drug response .
Source:
The OECM-1 human oral cavity squamous cell carcinoma cell line was derived from surgical resection of a primary tumor of a Taiwanese male patient .
Application
OECM-1 human oral squamous carcinoma cell line is suitable for studies of cancer cell signaling, epithelial-mesenchymal transition (EMT), metastasis, invasion, and cancer cell stemness.
Research Category
Cancer
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact [email protected].
Biochem/physiol Actions
Cancer Cells
Preparation Note
OECM-1 human oral cavity squamous carcinoma cell line should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Analysis Note
• Each vial contains ≥ 1X10⁶ viable cells.
• Cells are tested negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
• Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. 
