Merck, SCP0108-10MG, Cathepsin B Substrate, colorimetric

Name: Cathepsin B Substrate, colorimetric
Brand: Merck
SKU: SCP0108-10MG

Size:10 mg

Catalog Number: SCP0108-10MG

Pricing

Send an RFQ.

View RFQ List

Category

ECL Substrates

Pack Size10 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Cathepsin B, a bilobal protein, belongs to the papain-like family of cysteine proteases. It is produced as a preproenzyme. Its catalytic site is present at the interface between the two lobes. Cathepsin B has an occluding loop. It is located in the secretory vesicles of the neuronal cells. Active cathepsin B is found in the endosomal or lysosomal compartment under normal physiological conditions.
Biochem/physiol Actions
Cathepsin B is a lysosomal cysteine proteinase that metabolizes important molecules such as β-amyloid precursor protein into harmless fragments. Cathepsin B may be detected using the chromogenic substrate Z-Arg-Arg-pNA (z-arg-arg-p-nitroanalide) or flourogenic substrate Z-Arg-Arg-AMC (z-Arg-Arg-amino-4-methylcoumarin).
Cathepsin B possesses endopeptidase and exopeptidase activity. Active cathepsin B is mostly engaged in intracellular and extracellular protein turnover, which helps cells maintain homeostatic metabolic activity. It also participates in the regulation of pro-hormone and pro-enzyme activation, antigen processing, inflammatory reactions against antigens, tissue remodeling, and apoptosis. Cathepsin B plays a key role in acute pancreatitis. It also plays a vital role in lipid metabolism in atherosclerosis.

Specifications

General

UNSPSC Code	12352204
Web Name Suffix Override	≥95% (HPLC), lyophilized
Web Name Override	Cathepsin B Substrate
NACRES	NA.32
assay	≥95% (HPLC)
form	lyophilized
composition	Peptide Content, ≥80%
storage condition	protect from light
storage temp.	−20°C

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:

[email protected]

Please send inquiries directly to us in the “To” field. Emails sent via BCC, mass mailing, or with unrelated recipients may be automatically filtered and will not be processed.

Merck, SCP0108-10MG, Cathepsin B Substrate, colorimetric

Send an RFQ.

General

Notice

More from Merck.

Phosphomolybdic acid hydrate

Phosphomolybdic acid hydrate

Sodium dihydrogen phosphate dihydrate

Sephadex® LH-20

More from Merck.

Phosphomolybdic acid hydrate

Phosphomolybdic acid hydrate

Sodium dihydrogen phosphate dihydrate

Sephadex® LH-20