Merck, SRP3318-200UG, C1 Inhibitor human

Name: C1 Inhibitor human
Brand: Merck
SKU: SRP3318-200UG

Size:200 μg, C1inh, Plasma protease C1 inhibitor, Serpin G1, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC)

Catalog Number: SRP3318-200UG

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Category

Protease Inhibitors

Pack Size200 µg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Plasma protease C1 inhibitor is a member of the serpin family of structurally related proteins. Recombinant Human C1 inhibitor is a highly glycosylated glycoprotein containing 478 amino acid residues (52.8kDa), corresponding to amino acids 23-500 of the C1 inhibitor precursor, and is fully functional in its ability to inhibit the C1 complex. Glycosylated C1 inhibitor migrates at an apparent molecular weight of approximately 80-90kDa by SDS PAGE analysis under reducing conditions.
Biochem/physiol Actions
Plasma protease C1 inhibitor is the primary regulator of the immune complement system. C1 inhibitor is a protease inhibitor that functions to inhibit the complement system in order to prevent over-activation or spontaneous activation. Inhibition is achieved by binding to and irreversibly inhibiting the C1r and C1s proteases of the C1 complex, which has the effect of shutting down all subsequent downstream events in the complement activation cascade. C1 inhibitor can also inhibit various other proteases, including Kallikrein, Factor XIa, and Factor XIIa. Deficiencies in C1 inhibitor are the primary cause of hereditary angioedema (HAE, hereditary angioneurotic edema), a disease characterized by edema in the respiratory and gastrointestinal tracts. In certain clinical situations, the direct administration of C1 inhibitor can be used to treat HAE and certain other conditions.
Physical form
Lyophilized from 10mM Sodium Phosphate, pH 7.5.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Specifications

General

UNSPSC Code	12352202
Web Name Suffix Override	≥95% (HPLC), lyophilized powder, human recombinant, expressed in CHO cells
Web Name Override	C1 Inhibitor Peptide
NACRES	NA.32
biological source	human
recombinant	expressed in CHO cells
assay	≥95% (HPLC)
form	lyophilized
potency	≤2.6 nM IC50
mol wt	52.8 kDa
packaging	pkg of 200 μg
impurities	endotoxin, tested
UniProt accession no.	P05155
shipped in	wet ice
storage temp.	−20°C
Gene Information	human ... SERPING1(710)

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Merck, SRP3318-200UG, C1 Inhibitor human

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