Miltenyi, 130-046-201, CD71 MicroBeads, human

Background information
The CD71 antigen is also known as the transferrin receptor, which is essential for iron transport into proliferating cells. It is expressed on mesenchymal stromal cells (MSCs) in bone marrow1, on activated T and B lymphocytes, macrophages, and on all proliferating cells. It is up-regulated on lymphocytes during proliferative responses to antigens or mitogens but is not expressed on resting lymphocytes. Furthermore, CD71 is present on reticulocytes and erythroid progenitors in fetal liver, cord blood, and peripheral blood, but is downregulated as these cells differentiate into mature erythrocytes 2–4.

Downstream applications

- Enrichment of fetal early erythroid cells from maternal peripheral blood5,6
- Isolation of hematopoietic precursor cells committed to the erythroid lineage (BFU-E) when used in combination with the CD34 MultiSort Kit

Columns
For positive selection: MS, LS, XS, or autoMACS® Columns. For depletion: LD, D, or autoMACS Columns.

Overview
CD71 MicroBeads are developed for the positive selection or depletion of CD71-expressing cells from peripheral blood mononuclear cells (PBMCs), cord blood, bone marrow, or lymphoid tissue.