Miltenyi, 130-049-701, CD62L (L-selectin) MicroBeads, mouse

Background information
CD62L is highly expressed on naive T cells and down-regulated upon activation. It is also expressed on a small subset of memory T cells, the central memory T cells, which can be distinguished from naive T cells by their high expression of CD44. Furthermore, CD62L is expressed on most thymocytes, naive cytotoxic T cells, B cells, dendritic cells, macrophages, NK cells, neutrophils, and eosinophils.
For isolation of CD4+CD62L+ naive T cells, the CD4+CD62L+ T Cell Isolation Kit II is available.

Downstream applications
Naive T cells isolated following a MultiSort strategy were used for studies on cytokine expression,1,2 receptor signaling,3 and T cell activation by different antigen-presenting cells.4

Columns
For positive selection: MS, LS, XS, or autoMACS® Columns. For depletion: LD, D, or autoMACS Columns.

Overview
Mouse CD62L (L-selectin) MicroBeads were developed for the positive selection or depletion of T cell subsets from lymph nodes or spleen.