Miltenyi, 130-090-494, CD45RA MicroBeads, rat

Background information
The CD45RA isoform is B cell lineage–specific. It is neither expressed on thymocytes nor on any peripheral T cell subset. CD45RA was not detected on B cell progenitors in bone marrow.

Downstream applications
B cells separated with CD45RA MicroBeads can be used for analysis of B cell migration into non-lymphoid organs after infections, for evaluation of B cell responses after allograft transplantation, or to study the role of B cells in autoimmune diseases, such as arthritis or diabetes. Isolated B cells were used for adoptive transfer experiments to study autoimmunity and tolerance induction after xenogeneic thymus transplantation.1 Furthermore, isolated B cells were used for molecular analysis.2

Columns
For positive selection: MS, LS, XS, or autoMACS® Columns. For depletion: LD, D, or autoMACS Columns.

Overview
Rat CD45RA MicroBeads were developed for positive selection or depletion of B cells from blood, peripheral lymphoid organs, or from non-lymphoid tissues.