Miltenyi, 130-090-759, Anti-MHC Class II (OX6) MicroBeads, rat

Background information
The monoclonal antibody recognizes a non-polymorphic determinant of the MHC class II antigen RT1B, the rat homolog of the murine I-A antigen. MHC class II (RT1B) is expressed on antigen-presenting cells (APCs), notably on B cells, dendritic cells, and on most monocytes and macrophages where it is up-regulated upon activation. After activation, epithelial cells, endothelial cells as well as microglia and NK cells also become MHC class II+.

Downstream applications
Isolated MHC class II+ cells can be used for functional assays on antigen presentation and T cell stimulation. Additionally, Anti‑MHC Class II MicroBeads can be used for the enrichment of untouched T cells from lymph nodes by depletion of MHC class II+ cells.

Columns
For positive selection: MS, LS, XS, or autoMACS® Columns. For depletion: LD, D, or autoMACS Columns.

Overview
Anti-MHC Class II (OX6) MicroBeads have been developed for the positive selection or depletion of rat cells expressing the major histocompatibility complex (MHC) class II.