Miltenyi, 130-091-365, PTK7 (CCK-4) Antibody, anti-human, Biotin

Name: PTK7 (CCK-4) Antibody, anti-human, Biotin
Brand: Miltenyi
SKU: 130-091-365

Size:100 tests in 1 mL, Human peripheral blood mononuclear cells (PBMCs) were stained with Anti-PTK7 (CCK-4) antibodies as well as with CD303 (BDCA-2), CD141 (BDCA-3), or CD34 antibodies and analyzed by flow cytometry using the MACSQuant® Analyzer. Tandem Signal Enhancer has been used to increase binding specificity of tandem-dye–conjugated antibodies. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence or 4', 6-diamidino-2-phenyl

Catalog Number: 130-091-365

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Category

Biotin-Conjugated Secondary Antibodies

Pack Size100 tests

TagsMACS Antibodies Hybridomas

Description

Overview
The Anti-PTK7 (CCK-4) antibody (clone 188B) recognizes human protein tyrosine kinase-7 (PTK7). PTK7, also known as colon carcinoma kinase-4 (CCK-4), is a receptor protein tyrosine kinase (RPTK)–like molecule that contains a catalytically inactive tyrosine kinase domain. PTK7 was identified to be important for neural development as a regulator of planar cell polarity, being required for convergent extension movement and neural tube closure. Using the Anti-PTK7 (CCK-4) antibody, PTK7 expression was recently analyzed on blood and bone marrow cells. PTK7 was shown to be expressed on plasmacytoid dendritic cells, CD141 (BDCA-3)high type-2 myeloid dendritic cells, and CD34+ hematopoietic progenitor cells (HPCs). PTK7 was detected on early (CD34+ CD133+) and late (CD34+ CD133–) HPCs. In tonsils, PTK7 was also found on some T cells.

Specifications

General

Clone	188B
Clonality	monoclonal
Isotype	mouse IgG2aκ
Isotype control	Isotype Control Antibody, mouse IgG2a
Host	mouse
Type of antibody	Primary antibodies
Species reactivity	human
Antigen	PTK7 (CCK-4)
Molecular mass of antigen [kDa]	115
Entrez Gene ID	5754
RRID	AB_2661303, AB_2661302, AB_2801970, AB_2801991, AB_615145, AB_2661305, AB_615144, AB_615146, AB_2661306

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