Miltenyi, 130-092-656, CD357 (GITR) Antibody, anti-mouse, pure-functional grade

Name: CD357 (GITR) Antibody, anti-mouse, pure-functional grade
Brand: Miltenyi
SKU: 130-092-656

Size:1 mg in 0.5 mL, CD4+ mouse splenocytes were stained with Anti-GITR-PE (A) or Anti-GITR-APC (B) and CD25-Biotin/Anti-Biotin-APC or CD25-PE. Cells were analyzed by flow cytometry. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence.

Catalog Number: 130-092-656

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Category

Biotin-Conjugated Secondary Antibodies

Pack Size1 mg

TagsMACS Antibodies Hybridomas

Description

Overview
Clone DTA-1 specifically recognizes mouse CD357, also known as glucocorticoid-induced TNF-receptor (GITR) or TNFRSF18, a member of the TNF receptor superfamily. It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ regulatory T cells (Tregs). Activation of T cells upregulates GITR expression. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. GITR plays an important role in the function of CD4+CD25+ Tregs.

Specifications

General

Clone	DTA-1
Clonality	monoclonal
Isotype	rat IgG2bκ
Isotype control	Isotype Control Antibody, rat IgG2b
Host	rat
Type of antibody	Primary antibodies
Species reactivity	mouse
Antigen	CD357 (GITR)
Molecular mass of antigen [kDa]	23
Entrez Gene ID	21936
RRID	AB_2922043, AB_871551, AB_2659972, AB_871552, AB_871550, AB_2659973

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