Miltenyi, 130-092-852, CD146 Antibody, anti-human, Biotin

Name: CD146 Antibody, anti-human, Biotin
Brand: Miltenyi
SKU: 130-092-852

Size:100 tests in 1 mL, Human peripheral blood mononuclear cells (PBMCs) were spiked with human umbilical vein endothelial cells (HUVECs), stained with CD146 antibodies as well as with CD45 antibodies, and analyzed by flow cytometry using the MACSQuant® Analyzer. The Tandem Signal Enhancer has been used to increase binding specificity of tandem-dye–conjugated antibodies. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence or 4', 6

Catalog Number: 130-092-852

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Category

Mesenchymal Stem Cells

Pack Size100 tests

TagsMACS Antibodies Hybridomas

Description

Overview
Clone 541-10B2 recognizes the human CD146 antigen, also known as MUC18, MCAM, Mel‑CAM, or S-endo. CD146 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and contains five extracellular immunoglobulin (Ig)–like domains. CD146 possesses a limited tissue expression distribution, including endothelial cells, pericytes, smooth muscle cells, follicular dendritic cells, melanoma cells, and a sub-population of activated T lymphocytes. CD146 is also expressed on marrow stromal cells (MSCs).
CD146 functions as a Ca2+-independent cell adhesion molecule that is involved in heterophilic cell-cell interactions, and may be involved in the extravasion and/or homing of activated T cells. CD146 expression in melanoma is also directly associated with tumor growth and metastasis.

Specifications

General

Clone	541-10B2
Clonality	monoclonal
Isotype	mouse IgG1κ
Isotype control	Isotype Control Antibody, mouse IgG1
Host	mouse
Type of antibody	Primary antibodies
Species reactivity	human
Antigen	CD146
Molecular mass of antigen [kDa]	69
Distribution of antigen	dendritic cells, endothelial cells, epithelial cells, fibroblasts, T cells, stem cells, ES and iPS cells, mesenchymal stem cells, bone marrow, smooth muscle
Entrez Gene ID	4162
RRID	AB_2660768, AB_2660774, AB_2802063, AB_2802069, AB_2752172, AB_2752191, AB_2876898, AB_2819553, AB_871595, AB_871597, AB_871599, AB_2876899, AB_2819518, AB_2660772, AB_2660773

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