Miltenyi, 130-092-966, Anti-PSA-NCAM MicroBeads, human, mouse, rat

Background information
Anti-PSA-NCAM MicroBeads recognize polysialic acid (PSA), which is linked to the extracellular domain of the neural cell adhesion molecule (NCAM, CD56).1 PSA-NCAM, the highly polysialated form of NCAM, is predominantly expressed in embryonic and neonatal neural tissue2. In adult mammalian brain PSA-NCAM expression is restricted mainly to areas that retain neurogenic potential, such as the subventricular zone (SVZ)3 and the dentate gyrus of the hippocampus.4 PSA-NCAM is a marker for immature neuronal-committed progenitors that are permanently generated in the SVZ and migrate along a well-defined pathway, the rostral migratory stream, into the olfactory bulb where they differentiate into GABAergic and dopaminergic interneurons.3,5 PSA-NCAM positive neuronal precursors have been isolated from rat forebrain and from mouse SVZ tissue after depletion of A2B5+ glial progenitor cells.6-10

Columns
For positive selection: MS, LS, or autoMACS® Columns. For depletion: LD or autoMACS Columns.

Overview
Anti-PSA-NCAM MicroBeads have been developed for the positive selection or depletion of PSA-NCAM+ cells from tissue or cell culture.