Miltenyi, 130-093-394, A2B5 Antibody, anti-human/mouse/rat, pure

Name: A2B5 Antibody, anti-human/mouse/rat, pure
Brand: Miltenyi
SKU: 130-093-394

Size:100 µg in 1 mL, Mouse brain tissue postnatal day 1 was dissociated using the Neural Tissue Dissociation Kit (T). Brain cells were stained with Anti-A2B5 antibodies and analyzed by flow cytometry. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence.

Catalog Number: 130-093-394

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Category

Mouse Isotype Controls

Pack Size100 µg

TagsMACS Antibodies Hybridomas

Description

Overview
Clone 105HB29 recognizes the c-series ganglioside–specific antigen A2B5. The Anti-A2B5 antibody binds to glial progenitors from embryonic to adult human, murine, and rat tissue.
A2B5 is predominantly expressed in embryonic and neonatal neural tissue. In the adult mammalian brain, A2B5 expression is restricted mainly to areas which retain neurogenic potential such as the subventricular zone (SVZ). Thus, A2B5 is considered as a marker for immature glial-committed precursors which are permanently generated in the SVZ. Glial precursor cells are defined as cells that give rise to glial cell types, such as astrocytes and oligodendrocytes.
Ganglioside GT3 and its O-acetylated derivative are the principal A2B5-reactive gangliosides, and both antigens are down-regulated as the cells differentiate into mature oligodendrocytes. Therefore, A2B5 serves as a marker to monitor the maturation of oligodendrocyte progenitors in oligodendrocyte cultures.

Specifications

General

Clone	105HB29
Clonality	monoclonal
Isotype	mouse IgMκ
Isotype control	Isotype Control Antibody, mouse IgM
Host	mouse
Type of antibody	Primary antibodies
Species reactivity	human, mouse, rat
Antigen	A2B5
RRID	AB_2904622, AB_2904623, AB_2857622, AB_2857650, AB_1036062, AB_10828551, AB_2660801

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