Miltenyi, 130-093-583, Anti-MSCA-1 (W8B2) MicroBead Kit, human

Name: Anti-MSCA-1 (W8B2) MicroBead Kit, human
Brand: Miltenyi
SKU: 130-093-583

Size:for 1×109 total cells

Catalog Number: 130-093-583

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Category

Mesenchymal Stem Cells

TagsMACS Cell Separation Cell separation reagents MicroBeads and Isolation Kits Mesenchymal stem cells

Description

Background information
The Anti-MSCA-1 (W8B2) MicroBeads recognize the mesenchymal stromal cell antigen-1 (MSCA-1), which is identical to tissue non-specific alkaline phosphatase1.
MSCA-1 was shown to be restricted to MSCs in the CD271bright population in human bone marrow2. These CD271brightCD45dim MSCs have a much higher clonogenic capacity compared to the CD271+CD45+ fraction in bone marrow. Therefore, MSCA-1 is a highly specific marker to isolate MSCs with a high proliferative potential from bone marrow. MSCA-1 expression was not found on placenta-derived MSCs after culture3.
Antibodies against MSCA-1 show broad interspecies cross-reactivity, such as dog, pig, sheep, goat and monkey4.

Columns
MS, LS, XS, or autoMACS® Columns.

Overview
The Anti-MSCA-1 (W8B2) MicroBead Kit, based on the antibody clone W8B2, was developed for the positive selection of mesenchymal stromal cells (MSCs) with a high proliferative capacity, derived from bone marrow aspirates.

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