Miltenyi, 130-097-170, Anti-AN2 MicroBeads, human and mouse

Background information
AN21 is the mouse homolog of the rat NG2 and human MCSP protein. NG2 is a chondroitin sulfate glycoprotein that is expressed by glial progenitor cells in the developing and adult central nervous system (CNS) and by immature Schwann cells.
NG2/AN2+ glia has been identified as a fourth major glial cell type in the mammalian CNS that is distinct from other cell types2. NG2/AN2+ cells are precursors of oligodendrocytes and some protoplasmic astrocytes in the grey matter3. NG2/AN2 expression is down-regulated before the cells undergo terminal differentiation. However, a population of NG2/AN2+ cells remain in the white and grey matter after oligodendrocytes are generated4-6.
NG2/AN2+ glial cells participate in neuron-glial circuits by receiving presynaptic input from neurons and responding to neurotransmitters released by synapses7.
Many highly migratory neural tumors including melanomas express NG2/AN2.

Columns
For positive selection: MS, LS, or autoMACS® Columns. For depletion: LD or autoMACS Columns.

Overview
Anti-AN2 MicroBeads have been developed for positive selection or depletion of murine or human AN2+ glial cells.