Miltenyi, 130-097-456, AN2 Antibody, anti-human/mouse, Biotin

Name: AN2 Antibody, anti-human/mouse, Biotin
Brand: Miltenyi
SKU: 130-097-456

Size:100 tests in 1 mL, Mouse brain tissue postnatal day 7 was dissociated using the Neural Tissue Dissociation Kit (P) and the gentleMACS Dissociator. After re-expression of the AN2 antigen, mouse brain cells were stained with Anti-AN2-PE and analyzed by flow cytometry using the MACSQuant® Analyzer. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence.

Catalog Number: 130-097-456

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Category

Rat Isotype Controls

Pack Size100 tests

TagsMACS Antibodies Hybridomas

Description

Overview
AN2 is the mouse homolog of the rat NG2 and human MCSP proteins. NG2 is a chondroitin sulfate glycoprotein that is expressed by glial progenitor cells in the developing and adult central nervous system (CNS) and by immature Schwann cells. NG2/AN2+ glia has been identified as a fourth major glial cell type in the mammalian CNS that is distinct from other cell types. NG2/AN2+ cells are precursors of oligodendrocytes and some protoplasmic astrocytes in the gray matter. NG2/AN2 expression is down-regulated before the cells undergo terminal differentiation. However, a population of NG2/AN2+ cells remains in the white and gray matter after oligodendrocytes are generated. NG2/AN2+ glial cells participate in neuron-glial circuits by receiving presynaptic input from neurons and responding to neurotransmitters released by synapses. Many highly migratory neural tumors including melanomas express NG2/AN2.

Specifications

General

Clone	1E6.4
Clonality	monoclonal
Isotype	rat IgG1
Isotype control	Isotype Control Antibody, rat IgG1
Host	rat
Type of antibody	Primary antibodies
Species reactivity	human, mouse
Antigen	AN2
Molecular mass of antigen [kDa]	248
Entrez Gene ID	1464
RRID	AB_2651233, AB_2651234, AB_2889409, AB_2889408, AB_2651235

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