Miltenyi, 130-101-921, CD137 Antibody, anti-mouse, Biotin

Name: CD137 Antibody, anti-mouse, Biotin
Brand: Miltenyi
SKU: 130-101-921

Size:30 µg in 1 mL, Mouse spleen cells were either left unstimulated (left peak) or stimulated with plate-bound CD3 and soluble CD28 antibodies for 3 days. After that cells were stained with CD137 antibodies and analyzed by flow cytometry using the MACSQuant® Analyzer. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence or 4', 6-diamidino-2-phenylindole (DAPI) fluorescence, as in the case of tandem conjugates.

Catalog Number: 130-101-921

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Category

Biotin-Conjugated Secondary Antibodies

Pack Size30 µg

TagsMACS Antibodies Hybridomas

Description

Overview
Clone 17B5-1H1 reacts with mouse CD137, also known as 4-1BB or TNFRSF9, a member of the TNFR superfamily. It is expressed on the cell surface of T cells upon activation. The interaction of CD137 with its ligand, 4-1BBL, on antigen presenting cells (APCs) delivers a bidirectional costimulatory signal. CD137 engagement is shown to be required for CD8+ T cell survival and memory formation. The monoclonal antibody 17B5 is reported to have strong antagonistic effect in in vitro functional assays.

Specifications

General

Clone	17B5-1H1
Clonality	monoclonal
Isotype	hamster IgG2
Host	hamster
Type of antibody	Primary antibodies
Species reactivity	mouse
Antigen	CD137
Molecular mass of antigen [kDa]	25
Distribution of antigen	B cells, T cells, epithelial cells, fibroblasts, lymphocytes, macrophages, monocytes, dendritic cells
Entrez Gene ID	21942
RRID	AB_2654995, AB_2654996, AB_2654982, AB_2654997, AB_2733199, AB_2655000

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