Miltenyi, 130-101-931, CD252 (OX40L) Antibody, anti-mouse, Biotin

Name: CD252 (OX40L) Antibody, anti-mouse, Biotin
Brand: Miltenyi
SKU: 130-101-931

Size:30 µg in 1 mL, BALB/c splenocytes, either unstimulated (left image) or stimulated with Anti-IgM and CD40 antibodies for 3 days, were stained with CD252 (OX40L) antibodies as well as with CD19-FITC. Cells labeled with CD252 (OX40L)-Biotin were stained with Anti-Biotin-PE as well. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence.

Catalog Number: 130-101-931

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Category

Biotin-Conjugated Secondary Antibodies

Pack Size30 µg

TagsMACS Antibodies Hybridomas

Description

Overview
Clone RM134L recognizes CD252 (OX40L), a ligand of OX40 receptor, belonging to the TNF superfamily. Expression of CD252 can be induced on B cells, dendritic cells, macrophages, mast cells, natural killer (NK) cells, endothelial cells, and smooth muscle cells. Expression of the cognate receptor OX40 is found on activated CD4 cells, CD8 cells, regulatory T cells, NKT cells, NK cells, and neutrophils, but the function of OX40 signaling is extensively studied only in T cells. CD252 (OX40L)-OX40 interaction promotes the proliferation and surival of effector T cells, modulates cytokine production, suppresses the activity of natural regulatory T cells (nTreg), and inhibits the generation of inducible Treg cells.

Specifications

General

Clone	RM134L
Clonality	monoclonal
Isotype	rat IgG2bκ
Isotype control	Isotype Control Antibody, rat IgG2b
Host	rat
Type of antibody	Primary antibodies
Species reactivity	mouse
Antigen	CD252 (OX40L)
Molecular mass of antigen [kDa]	22
Distribution of antigen	B cells, dendritic cells, endothelial cells, mast cells, monocytes, T cells, leukemia cells, thymocytes, heart, spleen
Entrez Gene ID	22164
RRID	AB_2656668, AB_2656673, AB_2656670, AB_2656672, AB_2656675, AB_2656671, AB_2656674

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