Miltenyi, 130-101-946, CD44 Antibody, anti-mouse, Biotin

Name: CD44 Antibody, anti-mouse, Biotin
Brand: Miltenyi
SKU: 130-101-946

Size:30 µg in 1 mL, Balb/c spleen cells were stained with CD44 antibodies as well as with CD62L antibodies and analyzed by flow cytometry using the MACSQuant® Analyzer. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence or 4', 6-diamidino-2-phenylindole (DAPI) fluorescence, as in the case of tandem conjugates.

Catalog Number: 130-101-946

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Category

Mesenchymal Stem Cells

Pack Size30 µg

TagsMACS Antibodies Hybridomas

Description

Overview
Mouse CD44 is also known as Pgp-1, HCELL, HUTCH-I, HCAM, HERMES, and Ly-24. Clone IM7 reacts with murine CD44, an 80–95 kDa membrane glycoprotein. It is expressed by a variety of hematopoetic and non-hematopoetic cells. Different isoforms are generated by alternative splicing. Clone IM7 reacts with all isoforms and both allelic forms of CD44. CD44 functions as a receptor for hyaluronic acid (HA) and mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 expression is upregulated on naive T cells upon activation and high CD44 expression is maintained on memory T cells. Therefore, CD44 is often used to discriminate CD44high antigen-experienced T cells from CD44low (CD62L+) naive T cells.

Specifications

General

Clone	IM7.8.1
Clonality	monoclonal
Isotype	rat IgG2bκ
Isotype control	Isotype Control Antibody, rat IgG2b
Host	rat
Type of antibody	Primary antibodies
Species reactivity	mouse, non-human primate, other
Cross-reactivity	rhesus monkey (Macaca mulatta), cynomolgus monkey (Macaca fascicularis), chimpanzee (Pan troglodytes), baboon, human, pig, cow, horse, cat, dog
Antigen	CD44
Molecular mass of antigen [kDa]	83
Distribution of antigen	endothelial cells, T cells, red blood cells, stem cells, leukocytes, lymphocytes, cancer stem cells, CNS cells, mesenchymal stem cells, plasma cells, ES and iPS cells, bone marrow, kidney, skeletal muscle, skin
Entrez Gene ID	12505
RRID	AB_2658187, AB_2658183, AB_2658181, AB_2658180, AB_2819675, AB_2727594, AB_2658186, AB_2658190, AB_2905017, AB_2727570, AB_2658191, AB_2928468

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