Miltenyi, 130-102-169, CD207 (Langerin) Antibody, anti-mouse, APC

Name: CD207 (Langerin) Antibody, anti-mouse, APC
Brand: Miltenyi
SKU: 130-102-169

Size:30 µg in 1 mL, A single-cell suspension was prepared using the Epidermis Dissociation Kit. Cells were stained with CD207 (Langerin) antibodies conjugated to FITC (A), PE (B), APC (C), VioBlue (D), or PE-Vio770 (E) as well as with Anti-MHC Class II antibodies and analyzed by flow cytometry using the MACSQuant® Analyzer. Cells labeled with CD207 (Langerin)- Biotin (F) were stained with Anti-Biotin-PE in addition. Cell debris and dead cells were excluded from the analysis based on scatter sign

Catalog Number: 130-102-169

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Category

Biotin-Conjugated Secondary Antibodies

Pack Size30 µg

TagsMACS Antibodies Hybridomas

Description

Overview
CD207, also known as Langerin is a 48kDa transmembrane type II C-type lectin containing a single carbohydrate recognition domain in its extracellular region. Langerin is specifically expressed on epidermal Langerhans cells and dermal CD103+ dendritic cells. It displays Ca2+-dependent binding specificity for mannose, N-acetyl-glucosamine, and fucose and is involved in antigen recognition, uptake and transport to the Birbeck granules, whose formation is dependent on Langerin expression. The CD207 epitope shows trypsin as well as collagenase sensitivity.

Specifications

General

Clone	caa8-28H10
Clonality	monoclonal
Isotype	rat IgG2a
Isotype control	Isotype Control Antibody, rat IgG2a
Host	rat
Type of antibody	Primary antibodies
Species reactivity	mouse
Antigen	CD207 (Langerin)
Molecular mass of antigen [kDa]	38
Distribution of antigen	dendritic cells, Langerhans cells
Entrez Gene ID	246278
RRID	AB_2656238, AB_2656237, AB_2656239, AB_2656240, AB_2656236, AB_2656241

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