Miltenyi, 130-102-321, Notch2 Antibody, anti-mouse, APC

Name: Notch2 Antibody, anti-mouse, APC
Brand: Miltenyi
SKU: 130-102-321

Size:30 µg in 1 mL, Splenocytes from C57BL/6 mice, either stimulated with CD3 and CD28 antibodies for 3 days or unstimulated, were stained with Anti-Notch2 antibodies and analyzed by flow cytometry using the MACSQuant® Analyzer. Cells labeled with Anti-Notch2-Biotin were stained with Anti-Biotin-PE as well. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence.

Catalog Number: 130-102-321

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Category

Biotin-Conjugated Secondary Antibodies

Pack Size30 µg

TagsMACS Antibodies Hybridomas

Description

Overview
Clone HMN2-35 recognizes Notch2, a member of the Notch receptor family. Notch2 acts as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1. Notch signaling pathway is evolutionary conserved in the animal kingdom, where Notch receptors upon ligand binding undergo two proteolytic cleavages. The second cleavage releases the Notch intracellular domain (NICD), which translocates into the nucleus, forms an activator complex with the DNA binding protein RBP-J and activates genes of the enhancer of split locus. Notch signaling network regulates a number of biological processes involved in determination of cell fate, cell differentiation and apoptosis etc.

Specifications

General

Clone	HMN2-35
Clonality	monoclonal
Isotype	hamster IgG
Host	hamster
Type of antibody	Primary antibodies
Species reactivity	mouse
Antigen	Notch2
Molecular mass of antigen [kDa]	263
Entrez Gene ID	18129
RRID	AB_2653055, AB_2653057, AB_2653058, AB_2653054, AB_2653056, AB_2653053

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