Miltenyi, 130-102-627, CD61 Antibody, anti-mouse/rat, PE-Vio® 770

Name: CD61 Antibody, anti-mouse/rat, PE-Vio® 770
Brand: Miltenyi
SKU: 130-102-627

Size:30 µg in 1 mL, Mouse bone marrow suspension cells were stained with CD61 antibodies conjugated to (A) FITC, (B) PE, (C) APC, (D) PE-Vio770, and (E) Biotin as well as with Anti-Ter-119 antibodies conjugated to APC or PE and analyzed by flow cytometry using the MACSQuant® Analyzer. Cells labeled with CD61-Biotin were stained with Anti-Biotin-PE as well. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence or 4', 6-diamidino-2-ph

Catalog Number: 130-102-627

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Category

Biotin-Conjugated Secondary Antibodies

Pack Size30 µg

TagsMACS Antibodies Hybridomas

Description

Overview
Clone 2C9.G2 (HMβ3-1) recognizes a 110 kDa integrin β chain known as CD61 or Integrin β3. Owing to multiple α/β subunit combinations, integrins form an array of heterodimeric receptors, each recognising a multitude of ligands. CD61, in association with either αv (CD51) or αIIb (CD41) integrin, binds to fibrinogen, fibronectin, von Willebrand factor, prothrombin, disintegrins and thrombospondin. Due to binding to various extracellular matrix proteins and cellular receptors, integrins play a significant role in cell adhesion and cell movement. Furthermore, a pro-apoptotic function of CD61 has been suggested using a hepatocellular carcinoma (HCC) cell line and patient tissues. Expression of CD61 is found on platelets, B cell subsets, myeloid cells, mast cells, osteoclasts, endothelium, megakaryocytes, and smooth muscle cells.

Specifications

General

Clone	2C9.G2 (HMβ3-1)
Clonality	monoclonal
Isotype	hamster IgGκ
Host	hamster
Type of antibody	Primary antibodies
Species reactivity	mouse, rat
Antigen	CD61
Molecular mass of antigen [kDa]	84
Distribution of antigen	B cells, endothelial cells, fibroblasts, macrophages, mast cells, megakaryocytes, microglia, platelets, CNS cells, smooth muscle
Entrez Gene ID	16416
RRID	AB_2658828, AB_2658834, AB_2658829, AB_2658836, AB_2658830, AB_2658835, AB_2658832, AB_2658831, AB_2658833, AB_2658837

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