Miltenyi, 130-104-072, Anti-LGR5 MicroBeads, human

Background information
LGR5 positive cells were also shown to be crucial during the development and progression of cancer. It was shown that LGR5 crypt stem cells are the cells-of-origin in intestinal cancer and that CSCs in human colorectal cancer can be identified and isolated based on LGR5 expression.
LGR5 associates with Wnt-receptors and act as R-spondin receptor thereby playing a central role in the modulation of Wnt/β-catenin signaling in normal and neoplastic stem cells1,2. Initially described as a highly specific marker for stem cells in the small intestine, colon, hair follicle, stomach, and during kidney development3,4,5,6, LGR5 positive cells were also shown to be crucial during the development and progression of cancer. It was shown that LGR5+ crypt stem cells are the cells-of-origin in intestinal cancer and that CSCs in human colorectal cancer can be identified and isolated based on LGR5 expression7,8.

Columns
For positive selection: LS, XS, or autoMACS® Columns. For depletion: LD, CS, D, or autoMACS Columns.
Note: This product is not suitable for cell separation with an MS Column.

Overview
Positive selection or depletion of cells expressing human LGR5 antigen, such as colon cancer stem cells, or stem cells from the small intestine, colon, hair follicle, etc.