Miltenyi, 130-104-465, StemMACS™ Purmorphamine

Name: StemMACS™ Purmorphamine
Brand: Miltenyi
SKU: 130-104-465

Size:5 mg

Catalog Number: 130-104-465

Pricing

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size5 mg

TagsMACS Cell Culture and Stimulation Small Molecules

Description

Background information
StemMACS™ Purmorphamine is a small molecule that activates the Hedgehog signaling pathway by binding to the smoothened receptor (IC50 ~ 1.5 μM). Binding is competitive with respect to the smoothened antagonist cyclopamine. Purmorphamine has been used instead of sonic hedgehog for motor neuron differentiation and can promote osteogenesis in mesenchymal progenitor cells.

Applications
Published applications for Purmorphamine include:
- Activation of Hedgehog signaling1
- Motor neuron differentiation from pluripotent stem cells2,3
- Osteoblast differentiation from mesenchymal progenitors4,5,6
- Adipocyte differentiation from mesenchymal progenitors7

Overview
StemMACS™ Purmorphamine is a small molecule activator of hedgehog signaling.

Ordering

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