Miltenyi, 130-105-891, CD79b Antibody, anti-mouse, Biotin

Name: CD79b Antibody, anti-mouse, Biotin
Brand: Miltenyi
SKU: 130-105-891

Size:9 µg in 300 µL, Bone marrow cells from C57BL/6 mice were stained with CD79b antibodies as well as with CD45R antibodies and analyzed by flow cytometry using the MACSQuant® Analyzer. The specificity of the conjugated antibodies was confirmed by blocking the binding to the ligand, using pure unconjugated antibodies (left image). The FcR Blocking Reagent has been used to avoid Fc receptor–mediated antibody labeling. Cell debris and dead cells were excluded from the analysis based on scatter si

Catalog Number: 130-105-891

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Category

Biotin-Conjugated Secondary Antibodies

Pack Size9 µg

TagsMACS Antibodies Hybridomas

Description

Overview
Clone HM79-12 recognizes the mouse CD79b antigen, a 35-40kD Single-pass type I membrane protein also known as B-cell antigen receptor complex-associated protein beta chain (Igβ chain). The heterodimeric CD79 molecule is composed of an α chain (CD79a) and a β chain (CD79b) and is associated with surface immunoglobulins to form the B cell receptor. The CD79a/CD79b heterodimer facilitates the differentiation of pre-B cells from pro-B cells, surface expression of surface Ig, signal transduction following antigen recognition and endocytosis of recognized antigens. Crosslinking of CD79b in vitro by monoclonal antibodies activates pre-B cells but blocks terminal differentiation of all plasma cell isotypes. It was shown that a combination of CD79α and CD79β monoclonal antibodies can effectively deplete B cells from peripheral blood, spleen, bone marrow, and lymph nodes in mice.

Specifications

General

Clone	HM79-12
Clonality	monoclonal
Isotype	hamster IgG
Host	hamster
Type of antibody	Primary antibodies
Species reactivity	mouse
Antigen	CD79b
Molecular mass of antigen [kDa]	23
Distribution of antigen	B cells
Entrez Gene ID	15985
RRID	AB_2659221, AB_2659224, AB_2659226, AB_2659225, AB_2659223, AB_2659222, AB_2659220, AB_2659228, AB_2659229, AB_2659227

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