Miltenyi, 130-106-274, StemMACS™ A83-01

Name: StemMACS™ A83-01
Brand: Miltenyi
SKU: 130-106-274

Size:5× 2 mg

Catalog Number: 130-106-274

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Category

Small Molecule Inhibitors for Stem Cells

TagsMACS Cell Culture and Stimulation Small Molecules

Description

Background information
StemMACS™ A83-01 is a potent inhibitor of the TGF-beta, Activin and Nodal signaling pathway. A83-01 inhibits the activin receptor like kinases ALK4, ALK5, and ALK7 thereby preventing the phorphorylation of their downstream targets SMAD2 and SMAD3. A83-01 can be used instead of SB431542 and is more potent in inhibition towards AKL4, ALK5, and ALK7 with IC50 values of 45, 12, and 7.5 nM respectively. A83-01 exhibits only weak inhibition of the related kinases ALK1, ALK2, ALK3, and ALK6 in the BMP signaling pathway.

Overview
StemMACS™ A83-01 is a potent inhibitor of TGF-β type I receptor signaling.

Ordering

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