Miltenyi, 130-106-541, StemMACS™ PD0325901 in Solution

Background information
PD0325901 is a derivative of the MEK inhibitor CI-1040 and shows improved cell permeability and higher potency towards ERK1/2 (IC50=0.33 nM). In pluripotent stem cell research, inhibition of the MAPK signaling pathway with PD0325901 has been used to enhance reprogramming and sustain pluripotent stem cell selfrenewal.

Applications
Published applications for PD0325901 include:
- Naïve, ground state culture of murine ES and iPS cells (Ying et al.)
- Improved reprogramming efficiency when combined with SB431542 and Thiazovivin (Lin et al.)

Overview
StemMACS™ PD0325901 is a selective small molecule inhibitor of MEK (mitogen-activated protein kinase, MAPK/ERK kinase), a key component of the Ras/Raf/MEK/ERK signaling pathway.