Miltenyi, 130-108-075, C3a Receptor Antibody, anti-human, APC

Overview
Clone hC3aRZ8 recognizes the human C3a anaphylatoxin chemotactic receptor (C3aR) antigen, a 54 kDa seven transmembrane GTP-binding-protein–coupled receptor which belongs to the rhodopsin supergene family. C3aR is expressed by various cells, including cells of hematopoietic origin such as neutrophils and monocytes, but also non-hematopoietic cells such as renal proximal tubular epithelial cells or neural cells. C3aR functions as a cell surface receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, a C-terminal 77 amino acid cleavage product of the alpha chain of C3. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3aR. After C3a binding, the C3aR signaling results in chemotaxis, granule enzyme release, and superoxide anion production. C3aR binding on T cells promotes CD4+ and CD8+ T cell activation, proliferation, differentiation, and survival, independently of TCR signals.