Miltenyi, 130-108-984, Human IFN-α2a, research grade

Biological activity

Background information
Interferon alpha (IFN-α) cytokines belongs together with IFN-β to the type I interferon family, and is part of a cluster of proteins sharing more than 95% homology. IFN-α proteins are produced by several leukocytes, especially plasmacytoid dendritic cells, and share with all type I IFNs the same dimeric receptor (IFN-α R1/R2). IFN-α proteins induce a broad innate response to viral infections, but can also show immunomodulatory activities. IFN-α plays also a role in induction of fever and modulation of pain, by affecting the thermosensitivity of the hypothalamus and inducing prostaglandin-E2 release. An increased expression of IFN-α at tumor site favors dendritic cell activation and cytotoxic activity. IFN-α is usually produced as recombinant protein in two variants: IFN-α2a and IFN-α2b.

Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Overview
IFN-α2a stands for interferon α2a. Human IFN-α2a is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.