Miltenyi, 130-109-000, CD112 Antibody, anti-human, Biotin

Name: CD112 Antibody, anti-human, Biotin
Brand: Miltenyi
SKU: 130-109-000

Size:100 tests in 1 mL, K562 cells were stained with CD112 antibodies or with the corresponding isotype control (left peak). Flow cytometry was performed using the MACSQuant® Analyzer. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence.

Catalog Number: 130-109-000

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Category

Mouse Isotype Controls

Pack Size100 tests

TagsMACS Antibodies Hybridomas

Description

Overview
Clone R2.525 recognizes the human CD112 antigen, a single-pass type I membrane protein, which is also known as nectin-2, herpesvirus entry mediator B (HveB), or poliovirus receptor-related protein 2 (PRR2). Nectins are Ca2+-independent cell adhesion molecules that consist of 4 members: CD111 (Nectin-1), CD112 (Nectin-2), CD113 (Nectin-3), and Nectin-4. CD112 is one of the plasma membrane components of adherens junctions and is widely expressed in human tissues, including hematopoietic cells. It is also over-expressed in various cancers, e.g. breast and ovarian cancers. It has been reported to regulate cell adhesion between epithelial cells through the formation of trans-dimers between adjacent cells. CD112-mediated cell adhesion induces the formation of E-cadherin-based adherens junctions followed by the formation of claudin-based tight junctions. In addition to its function as a cell adhesion molecule, previous studies have suggested that CD112 acts as an organizer of Sertoli cell–spermatid junctions in the testis and of synapse formation by neurons and as an entry receptor for viruses. CD112 is also known to be one of the ligands of CD226 (DNAM-1) and TIGIT.

Specifications

General

Clone	R2.525
Clonality	monoclonal
Isotype	mouse IgG1κ
Isotype control	Isotype Control Antibody, mouse IgG1
Host	mouse
Type of antibody	Primary antibodies
Species reactivity	human
Antigen	CD112
Molecular mass of antigen [kDa]	55
Distribution of antigen	endothelial cells, epithelial cells, leukocytes, testicle
Entrez Gene ID	5819
RRID	AB_2654545, AB_2889426, AB_2654546, AB_2889425

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