Miltenyi, 130-110-489, StemMACS™ DAPT

Name: StemMACS™ DAPT
Brand: Miltenyi
SKU: 130-110-489

Size:5 mg

Catalog Number: 130-110-489

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size5 mg

TagsMACS Cell Culture and Stimulation Small Molecules

Description

Background information
StemMACS™ DAPT is a cell-permeable dipeptide that inhibits the protease γ-secretase, a key component of the Notch signaling pathway. The Notch pathway is involved in various developmental cell fate and lineage decisions, making the small molecule inhibitor DAPT a valuable tool for the modulation of stem cell differentiation in cell culture. In addition, γ-secretase plays a role in processing of amyloid precursor protein (APP) to β-amyloid, a component of the senile plaques characteristic for Alzheimer’s disease. Inhibition of γ-secretase by DAPT has been shown to cause a dose-dependent reduction of β-amyloid levels in primary neuronal cultures as well as in vivo.

Applications
Published applications for DAPT include:
- Differentiation of human PSCs into retinal pigment epithelium (RPE) cells1
- Neural differentiation of human PSCs2
- Pancreatic differentiation of human PSCs3
- Nociceptor differentiation from human PSCs4

Overview
StemMACS™ DAPT is a small molecule inhibitor of gamma-secretase that prevents Notch signaling.

Ordering

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