Miltenyi, 130-110-491, StemMACS™ IWR-1-endo

Name: StemMACS™ IWR-1-endo
Brand: Miltenyi
SKU: 130-110-491

Size:5 mg

Catalog Number: 130-110-491

Pricing

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Category

Small Molecule Inhibitors for Stem Cells

Pack Size5 mg

TagsMACS Cell Culture and Stimulation Small Molecules

Description

Background information
StemMACS™ IWR-1-endo is a potent inhibitor of the Wnt signaling pathway. It stabilizes the Axin-scaffolded destruction complex, thereby promoting β-catenin phosphorylation and degradation. In cell culture reporter assays IWR-1-endo inhibits Wnt/β-catenin signaling with an IC50 value of 180 nM.

Applications
Published applications for IWR-1-endo include:
- Cardiac differentiation of human PSCs1, 2
- Differentiaton of human PSCs into alveolar epithelial cells3

Overview
StemMACS™ IWR-1-endo is an inhibitor of the Wnt signaling pathway.

Ordering

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