Miltenyi, 130-112-947, Human IL-35, research grade

Biological activity

Background information
Human interleukin 35 (IL-35) consists of the IL-12 subunit alpha and the IL-27 subunit beta which is also known as EBI3. It plays a role in immune suppression and is produced by regulatory T cells and macrophages. IL-35 suppresses effector T cell proliferation, inhibits Th17 cell development, and promotes the conversion of T cells and B cells into regulatory T and B cells. Additionally, it is involved in regulation of tumor growth, autoimmune disease, and infectious tolerance.

Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Overview
Human IL-35 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.