Miltenyi, 130-113-322, CD123 Antibody, anti-human, APC

Name: CD123 Antibody, anti-human, APC
Brand: Miltenyi
SKU: 130-113-322

Size:100 tests in 200 µL, Human peripheral blood mononuclear cells (PBMCs) were stained with CD123 antibodies as well as with CD303 (BDCA-2) antibodies and analyzed by flow cytometry using the MACSQuant® Analyzer. The Tandem Signal Enhancer has been used to increase binding specificity of tandem-dye–conjugated antibodies. For all other conjugates the FcR Blocking Reagent has been used to avoid Fc receptor–mediated antibody labeling. Cell debris and dead cells were excluded from the analysis base

Catalog Number: 130-113-322

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Category

Antibody Labeling Kits

Pack Size100 tests

TagsMACS Antibodies Hybridomas

Description

Overview
CD123 is also known as interleukin 3 (IL-3) receptor α-chain and is the primary low-affinity subunit of the IL-3 receptor. CD123 associates with CD131, the common β-chain of the IL-3, IL-5, and GM-CSF receptor, to form the high-affinity IL-3 receptor. The IL-3 receptor is involved in cell signaling for cell growth and differentiation. In peripheral blood, the CD123 antigen is expressed at high levels only on plasmacytoid dendritic cells and basophilic granulocytes but at low levels also on monocytes, eosinophilic granulocytes, myeloid dendritic cells, and subsets of hematopoietic progenitor cells.

Specifications

General

Clone	AC145
Clonality	monoclonal
Isotype	mouse IgG2aκ
Isotype control	Isotype Control Antibody, mouse IgG2a
Host	mouse
Type of antibody	Primary antibodies
Species reactivity	human
Antigen	CD123
Molecular mass of antigen [kDa]	41
Distribution of antigen	B cells, granulocytes, monocytes, macrophages, endothelial cells, mast cells, megakaryocytes, red blood cells, eosinophils, basophils, bone marrow, brain, placenta
Entrez Gene ID	3563
RRID	AB_244208, AB_2661231, AB_2726104, AB_2726107, AB_2726379, AB_2726381, AB_2726103, AB_2726384, AB_2726378, AB_2726377, AB_2726101, AB_2726376, AB_2751812, AB_2726099, AB_2726380, AB_2726105, AB_2726102, AB_2726100, AB_2751756, AB_2726383, AB_2726106, AB_2726382

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