Miltenyi, 130-113-898, CD44 Antibody, anti-human, PE-Vio® 770

Name: CD44 Antibody, anti-human, PE-Vio® 770
Brand: Miltenyi
SKU: 130-113-898

Size:30 tests in 60 µL, A mixture of cells from U937 (CD44+) and 1881 (CD44–) cell lines was stained with CD44 antibodies and analyzed by flow cytometry using the MACSQuant® Analyzer. The Tandem Signal Enhancer has been used to increase binding specificity of tandem-dye–conjugated antibodies. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence or 4', 6-diamidino-2-phenylindole (DAPI) fluorescence, as in the case of tandem conjugat

Catalog Number: 130-113-898

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Category

Mesenchymal Stem Cells

Pack Size30 tests

TagsMACS Antibodies Hybridomas

Description

Overview
Clone DB105 recognizes the CD44 antigen. CD44 is a marker for many types of cancer stem cells (CSCs), including breast CSCs that possess higher tumorigenicity and metastatic potential, colorectal, pancreatic, and prostate CSCs. In addition, expression was observed in several cancers as well as on carcinoma cell lines. Here, CD44 plays a role in cancer cell migration and matrix adhesion in response to a cellular microenvironment, thus enhancing cellular aggregation and tumor cell growth. CD44 is also expressed on mesodermal cells, such as hematopoietic, fibroblastic, and glial cells.

Specifications

General

Clone	DB105
Clonality	monoclonal
Isotype	mouse IgG1κ
Isotype control	Isotype Control Antibody, mouse IgG1
Host	mouse
Type of antibody	Primary antibodies
Species reactivity	human, non-human primate
Cross-reactivity	rhesus monkey (Macaca mulatta)
Antigen	CD44
Molecular mass of antigen [kDa]	79
Distribution of antigen	stem cells, chondrocytes, endothelial cells, epithelial cells, leukocytes, lymphocytes, myeloid leukemia cells, red blood cells, T cells, cancer stem cells, CNS cells, mesenchymal stem cells, plasma cells, ES and iPS cells, bone marrow, kidney, skeletal muscle, skin
Entrez Gene ID	960
RRID	AB_2726113, AB_2922078, AB_2922045, AB_2733522, AB_2726388, AB_2726385, AB_2726109, AB_2726108, AB_2726390, AB_2733523, AB_2726389, AB_2726110, AB_2726111, AB_2726387, AB_2726112, AB_2726386

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