Miltenyi, 130-115-985, CD115 Antibody, anti-mouse, APC, REAlease®

Name: CD115 Antibody, anti-mouse, APC, REAlease®
Brand: Miltenyi
SKU: 130-115-985

Size:30 µg in 200 µL, Bone marrow cells from C57BL/6 mice were stained with REAlease CD115-PE (B) or with the corresponding REAL Control (A). REAlease CD115-PE was released using the REAlease Release Reagent (C). To show epitope accessibility after REAlease Complex release, the cells were washed with the REAlease Stop Reagent and restained with REAlease CD115-PE (D). Cells were labeled with Anti-Ly-6C antibodies in addition and analyzed by flow cytometry using the MACSQuant® Analyzer. Cell debri

Catalog Number: 130-115-985

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Category

Recombinant Antibodies

Pack Size30 µg

TagsMACS Antibodies Releasable antibodies

Description

Overview
Clone REAL272 is an antibody fragment derived from the full CD115 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL272 recognizes the protein tyrosine kinase transmembrane receptor for macrophage colony-stimulating factor (M-CSF), also known as CSF-1 and interleukin 34 (IL-34). CD115 is a single-pass type I membrane protein. Receptor activation induces homo-dimerization, which leads to phosphorylation and ubiquitinylation of intracellular residues. CD115 is expressed on mouse monocytes, macrophages, and osteoclasts, as well as on common dendritic cell precursors and macrophage/dendritic cell precursors.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Specifications

General

Clone	REAL272
Clonality	monoclonal
Isotype control	Control Antibody
Host	cell line
Type of antibody	Releasable antibodies, Primary antibodies, Recombinant antibodies
Species reactivity	mouse
Antigen	CD115
Distribution of antigen	macrophages, monocytes, osteoclasts, dendritic cells
RRID	AB_2811311, AB_2751450, AB_2783913

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