Description
Overview
Clone REAL1316 is an antibody fragment derived from the full APC (DP2.5) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1316 recognizes the human APC (DP2.5) which plays a critical role in several cellular processes. The APC protein acts as a tumor suppressor. It promotes rapid degradation of CTNNB1 and participates in Wnt signaling pathway as a negative regulator. APC (DP2.5) is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
