Description
Overview
Clone REAL1498 is an antibody fragment derived from the full AMACR antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1498 recognizes AMACR (Alpha-methylacyl-CoA racemase),which belongs to the family of isomerases, specifically the racemases and epimeraseslocalize to mitochondria and peroxisomes. Mutations in the AMACR gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Increased levels of AMACR protein concentration and activity are associated with prostate-,breast- and, colon cancer, and the enzyme is used widely as a biomarker (known in cancer literature as P504S) in biopsy tissues.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
