Miltenyi, 130-136-458, BCMA CAR Detection Reagent, human, Vio® Bright B515

Overview
The BCMA CAR Detection Reagent, anti-human, REAfinity™ has been developed for the detection of transduced T cells that are engineered to express BCMA-specific chimeric antigen receptors (CAR) on the cell surface, which recognize human BCMA antigen.
The BCMA CAR Detection Reagent is an antigen based detection reagent conjugated to biotin, FITC, PE, APC and Vio® Bright B515. It contains a recombinantly expressed fusion protein consisting of the human BCMA extracellular domains and a specifically mutated human IgG1 Fc region.The engineered BCMA CAR T cells can be detected via the recognition of the BCMA protein, and identified by flow cytometry. The mutated human IgG1 Fc region of the BCMA CAR Detection Reagent abolishes their binding to Fcγ receptors. This allows for background-free analysis and eliminates the need for additional blocking steps, such as using a FcR blocking reagent.