Miltenyi, 130-136-487, PepTivator® WNV Envelope 2, research grade

Background information
The West Nile virus (WNV) belongs to the family of flaviviruses. It was first described in Africa already in 1937 but meanwhile it can be found worldwide. WNV is a primary mosquito transmitted viral infection to humans and mainly causes West Nile fever, headache, body aches, or a rash. In some cases can lead to severe neurological diseases such as encephalitis and meningitis. Up to date are no vaccines available to prevent infection, nor specific antiviral compounds to treat West Nile virus disease. PepTivator WNV Envelope 2 – research grade covers aa 535–791 of the genome polyprotein. The WNV genome is translated as a single polyprotein, which is then cleaved into three structural proteins (C, M, and E) and seven non-structural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5).

Overview
PepTivator WNV Envelope 2 (West Nile Virus, strain NY-99), is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the sequence of the WNV Envelope 2 domain (West Nile virus, strain NY-99) (UniProt Acc. no. Q9Q6P4).
In vitro stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells. For immunogenic epitopes from tropical fever viruses (Dengue, Zika, West Nile Virus) see also our portfolio of MACSpep single peptides.