Description
Background information
The human respiratory syncytial virus (RSV) is an RNA virus of the paramyxoviridae family. It is the most common cause of viral infections of the lower respiratory tract in infants and young children. The 298 aa Glycoprotein G, also termed as Major surface glycoprotein G, is known to play a role in the attachment of the virion to the host cell membrane and subsequently initiating the infection.
The PepTivator Peptide Pools have been specially developed for efficient in vitro stimulation of antigen-specific CD4+ and CD8+ T cells, as peptides of 15 amino acid length with 11 amino acid overlap represent the optimized solution for stimulating both CD4+ and CD8+ T cells in various applications. Stimulation of T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and upregulation of activation markers, which then allows the detection or isolation of antigen-specific T cells.
Quantitative, phenotypical, or functional analysis of antigen-specific T cell immunity can provide important information on the natural course of immune responses.
Overview
PepTivator RSV Glycoprotein G is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the sequence of the Major surface Glycoprotein G of the human respiratory syncytial virus (RSV), (UniProt ID: P03423).
In vitro stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells.
