Description
Background information
The human respiratory syncytial virus (RSV) is an RNA virus of the paramyxoviridae family. It is the most common cause of viral infections of the lower respiratory tract in infants and young children.
The PepTivator RSV-Select contains 180 peptides which cover important MHC-I and MHC-II epitopes from both main RS virus subtypes RSV-A [strain A2] and RSV-B [strain B1]. This PepTivator comprises epitopes from RSV glycoprotein G, gatrix -, M2-1 -, RNA-L -, NS1 - as well as nucleoprotein. Epitopes derived from the RSV Fusion protein F0 sequence are provided in a separate product, the PepTivator RSV Fusion Select.
The PepTivator Peptide Pools have been specially developed for efficient in vitro stimulation of antigen-specific CD4+ and CD8+ T cells in various applications. Stimulation of T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and upregulation of activation markers, which then allows the detection or isolation of antigen-specific T cells.
Quantitative, phenotypical, or functional analysis of antigen-specific T cell immunity can provide important information on the natural course of immune responses in healthy or immunocompromised individuals.
Overview
PepTivator RSV Select is a pool of lyophilized peptides, covering important MHC-I and MHC-II epitopes of the following RSV proteins: Major surface Glyocoprotein G [P03423, O36633], Matrix Protein [P0DOE7, O42049], M2-1 protein [P04545], SH protein [P0DOE5], RNA-L Protein [P28887, O36635], NS1 protein [P0DOE9, O42083] and Nucleoprotein [P03418, O42053].
In vitro stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells.
