Miltenyi, 130-136-929, MACSpep KRAS G12D (GADGVGKSA) HLA-C*08

For more detailed biochemical properties of the peptide sequences please refer to the individual product data sheets.
Please note that certain peptide sequences are known to exhibit promiscuous binding and, as such, cannot be attributed to a single dominant MHC allele. These peptides may associate with multiple MHC alleles, depending on factors such as binding affinity and solubility. The product data sheet provides further MHC alleles that may be compatible with the specific peptide of interest. The main MHC allele indicated in the product name has been carefully selected based on published scientific literature and affinity prediction analyses, without a guarantee for completeness or absolute accuray.

Overview
MACSpep single peptides have been specifically developed for loading onto MHC multimers using the MHC MACSimer FleX Kits for the detection and analysis of antigen-specific T cells with maximum flexibility. They cover a broad range of different MHC alleles and come with a tailored MHC peptide-loading protocol, enabling fast and convenient TCR and epitope screening. Alternatively, MACSpep single peptides can be used for epitope-specific stimulation or expansion of T cells in vitro, as well as for the analysis of cancer-directed immune responses under various conditions. The Kirsten rat sarcoma virus (KRAS) gene is the most commonly mutated oncogene in human cancers, and its activation promotes tumor cell survival and proliferation. KRAS mutations have been frequently associated with worse prognosis in certain types of cancerous diseases and they are broadly recognized as promising targets for engineered T cell therapy (e.g., neoantigen-directed TCR T cell therapy).